---
title: "HiC-Seq"
search_description: "IGATech’s Hi-C sequencing services provide comprehensive 3D genome mapping to study chromatin interactions, genome architecture, and gene regulation. Ideal for epigenetics, cancer research, structural genomics and for de novo assembly scaffolding. Explore spatial genome insights with our advanced solutions."
published: 2026-03-23 09:18:19.192802+00:00
locale: "it"
---

# HiC-Seq

[Request a quote](https://igatechnology.com/igatech/contacts/#contact-form)

## Technologies

![NovaSeq X Plus](/media/images/Illumina_NovaSeq_XPlus_Left_561x375.width-500.png)

### NovaSeq X Plus

The NovaSeq X Plus is a powerful and scalable ultra-high-throughput sequencing system that supports the broadest range of applications and study sizes. Unrivaled data quality using Illumina's proven SBS chemistry has made the NovaSeq X Plus the instrument of choice for all major genome centers and leading institutions throughout the world. Producing up to 25 billion reads \(7.5 Tbp\) per flowcell, yielding up to 120 human genomes in about 2 days at full capacity.

![HiC-Seq](/media/images/2.width-500.jpg)

### HiC-Seq

Chromatin interactions are knonw to play an important role in trans-regulatory mechanisms of transcription and chromosome organization. Beside the biologically relevant signals acquired by HiC data \(deviation from expected\), the proximity contact matrix \(expected\) has become a state of-the-art technique to assemble genome at chromosome scale and possibly to phase alterantive alleles to the same extent to delivery complete diploid genome assemblies.

## **Accessing the third dimension of DNA**

![spaghettiDNA](/media/images/spaghettiDNA.width-1500.png)

IGATech offers Hi-C sequencing services, utilizing this powerful technology to refine genome assemblies and unravel the complex organization of chromatin within the nucleus. Our Hi-C services provide essential insights into how the genome is functionally compartmentalized, influencing gene expression and cellular functions.

**Refinement of Genome Assembly**

Our Hi-C data plays a crucial role in refining genome assemblies by providing comprehensive information on the physical proximity of DNA segments. This allows researchers to determine how chromosomes fold and interact within the three-dimensional space of the nucleus, enhancing the accuracy of genome assembly. The spatial organization captured by Hi-C data is instrumental in bridging gaps and resolving ambiguities often encountered in genome assembly processes, leading to more accurate and contiguous assemblies.

**Understanding Chromatin Structure**

Hi-C sequencing offers an unparalleled view of the chromatin architecture, revealing how it is organized and partitioned within the nucleus. This method enables the identification of:

- **A/B Compartments**: Hi-C data allows for the delineation of active \(A\) and inactive \(B\) compartments, showing regions of open chromatin associated with active gene transcription versus more condensed areas. This compartmentalization is crucial for understanding the regulatory mechanisms influencing gene expression.
- **Topologically Associating Domains \(TADs\)**: Within these compartments, Hi-C helps identify TADs, regions where chromatin is highly self-interactive. These domains are fundamental in gene regulation, as they often contain genes and regulatory elements that interact more frequently with each other than with elements outside the domain.

![unnamed-chunk-5-1](/media/images/unnamed-chunk-5-1.width-1500.png)

**Specialized Bioinformatics Support**

To extract meaningful insights from complex Hi-C data, specialized bioinformatics support is essential. Our team of expert bioinformaticians utilizes advanced algorithms and custom analytical tools designed specifically for Hi-C data analysis. We provide:

- **Comprehensive Data Analysis**: From processing raw data to visualizing interaction maps and identifying structural features within the genome.
- **Customized Data Interpretation**: Tailored analysis that aligns with specific research goals, whether you are investigating chromatin dynamics, gene regulation, or the effects of genetic variants on chromatin structure.
- **Integration with Other Genomic Data**: We help integrate Hi-C data with other genomic datasets, such as ChIP-seq or RNA-seq, to provide a holistic view of genomic and epigenomic mechanisms.

**Technical Specifications and Service Details**

For more detailed information on how our Hi-C sequencing services can be integrated into your research projects, please contact us. We are committed to providing you consultancy to plan your experiment and arrange sample shipping conditions.

## Terms and Conditions

- [Privacy Information.pdf](/documents/12/Privacy_Information_rev00.pdf)
- [Human samples clearance.pdf](/documents/13/__Human-samples_clearance.pdf)
- [Shipping and Packaging Guidelines.pdf](/documents/9/SHIPPING_AND_PACKAGING_GUIDELINES.pdf)
- [rev05 Terms and Conditions.pdf](/documents/137/__M12_01_rev05_Terms_and_Conditions.pdf)